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The effect of repeated contralateral treatment with the kappa-opioid receptor agonist U-50,488H {trans-(+/-)-3,4-dichloro-N-methyl-N-[2-(1-pyrrolidinyl)-cyclohexyl]-benzene acetamide methanesulphonate} was investigated in rats with unilaterally induced adjuvant arthritis.

Anti-inflammatory effects of contralateral administration of the κ-opioid agonist U-50,488H in rats with unilaterally induced adjuvant arthritis