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Cytokine-induced hepatic serum amyloid A (SAA) synthesis is the critical step in the pathogenesis of AA amyloidosis secondary to rheumatoid arthritis (RA). This study was conducted to provide more insight into the mechanism of SAA production in hepatocytes and its regulation.

An active metabolite of leflunomide, A77 1726, inhibits the production of serum amyloid A protein in human hepatocytes