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To determine whether steroids inhibit the production of inflammatory cytokines by the inhibition of nuclear factor kappaB (NF-kappaB) activation in fibroblast-like rheumatoid synoviocytes (FLSs) under inflammatory conditions, and to determine whether steroids stimulate the induction of synthesis of the inhibitory protein IkappaB-alpha in the anti-inflammatory immune response of these cells.

rheumatology

Glucocorticoid‐mediated repression of inflammatory cytokine production in fibroblast‐like rheumatoid synoviocytes is independent of nuclear factor‐κB activation induced by tumour necrosis factor α