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We are pleased to introduce this Quarterly Journal of Medicine Cancer Review Series that seeks to highlight not only the extraordinary progress that has been made in cancer research, diagnostics, therapeutics and disease outcomes but also the persistent challenges that lay ahead. We are sincerely honored to feature, for our introductory review article, a clinical perspective on Lynch Syndrome in the twenty-first century authored by its namesake, Dr Henry Lynch, and his colleagues Drs Tiwari and Roy. Lynch Syndrome (LS—hereditary nonpolyposis colorectal cancer) represents ∼3% of all colorectal cancers worldwide, typically presents at a significantly younger …

QJMcancer review series introduction