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Due to the ubiquitous nature of latent tuberculosis, and the unpredictability of its transition to active tuberculosis, there will always be a requirement to depart from the principle of diagnostic parsimony (so-called Occam’s razor)1 by invoking dual infection (in which Mycobacterium tuberculosis plays a part) in the aetiopathogenesis of disease in sites such as the lung and meninges even though, at those sites, it is exceptional for disease to be caused by more than one pathogen at a …

Caveats to the application of diagnostic parsimony