English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

The increased mortality and morbidity from cardiovascular disease associated with diabetes mellitus (DM) is well known.1 Patients with DM but no previous myocardial infarction (MI) have a risk of MI similar to that of non-diabetic patients with a previous history of MI,1 and mortality from acute MI in patients with DM is double that in non-diabetic individuals.2,,3 Five-year mortality in patients with DM hospitalized with MI is 75%:3 higher than that for many malignant diseases. In spite of more aggressive and interventional therapies for MI, mortality remains significantly higher in patients with DM, compared with those without.4 There are several possible explanations for this increased mortality, including the presence of more severe, extensive and diffuse coronary artery lesions, diabetic cardiomyopathy, diabetic autonomic neuropathy, and the pro-thrombotic tendency in DM.5The concept of infusing glucose together with insulin and potassium (GIK) to protect ischaemic myocardium was pioneered by Sodi-Pallares et al. more than 40 years ago.6 Many studies lacked statistical power to demonstrate a clear benefit of this intervention compared to controls, and many trials had poor randomization techniques.7 In the DIGAMI study, insulin-glucose intravenous infusion in an acute MI followed by …

The benefits of insulin therapy following acute myocardial infarction revisited