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Summary Objective We examined whether auricular acupressure (AA) at four specifically preselected AA points can alleviate knee pain and decrease non-steroidal anti-inflammatory drugs (NSAIDs) consumption and its adverse effects for osteoarthritis patients. Methods Sixty-two patients (more than 40 years) with knee osteoarthritis of Kellgren–Lawrence grades of I or II upon radiographic classification were enrolled in this randomized, sham-controlled prospective study, and divided into two groups (AA group and control group). The AA group received true AA by embedding vaccaria seeds at four specific AA points (knee joint, shenmen, subcortex and sympathesis) ipsilateral to the knee osteoarthritis site, while the control group received four nonacupuncture points on the auricular helix. Visual analog scale (VAS), the Western Ontario and McMaster Universities Arthritis Index (WOMAC) score, the number of patients who needed celecoxib pills and adverse effects were recorded. Results VAS and WOMAC scores in the AA group were significantly lower than that in the control group (P &amp;lt; 0.05) at Days 3 and 7 postsugery. The VAS and WOMAC score were significantly decreased after the treatment in the AA group compared with that before the treatment (P &amp;lt; 0.05). The use of celebrex is significantly lower in the AA group than in the control group (P &amp;lt; 0.05), no major side effects were observed during the auricular acupressure treatment. Conclusion Auricular acupressure plays a role in analgesic effect and can effectively decrease NSAIDs requirements without causing adverse events for the treatment of human knee osteoarthritis.

Auricular acupressure for treating early stage of knee osteoarthritis: a randomized, sham-controlled prospective study