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Background Retinitis pigmentosa (RP) encompasses a group of hereditary retinal diseases that result in progressive loss of rod and cone photoreceptors. It occurs in approximately one in 4000 individuals, with a worldwide prevalence of 1.5 million affected individuals. Aim of the Work This study aimed measure the subfoveal choroidal thickness and outer retinal layer thickness in patients with Retinitis Pigmentosa and correlate them with visual acuity. Methods Fifty eyes of clinically and electrophysiologically confirmed retinitis pigmentosa patients compare to fifty eyes of normal healthy individuals of the same age group as controls. Both groups were investigated for best corrected visual acuity (BCVA)(LogMAR) and Swept Source optical coherence tomography (SS-OCT) evaluating outer retinal layer thickness (ORL), central foveal thickness and subfoveal thickness (SFCT) and the integrity of inner segment-outer segment junction IS/OS as being (Intact (+) or disrupted (-)), Results Mean ages were 34.5 ± 11.3 years for controls versus 38.8 ±12.8 years for RP patients (p &amp;gt; 0.05). Mean BCVA (logMAR) was 0.86 for RP group vesus 0.02 for control group. Mean subfoveal choroidal thickness (SFCT) measurements were significantly lower in RP group (288.4 µm) than control group (333.7µm) (P value = 0.008). Significant difference was found between choroidal thickness and BCVA (logMAR) (p-value &amp;lt;0.001). Presence of IS/OS was significantly correlated with BCVA (log MAR) (p value=0.0001). And finally, there was moderate negative correlation between central foveal thickness and BCVA (logMAR) (r = -0.414, p-value = 0.012). Conclusion Submacular choroidal thickness as measured by SS–OCT, is significantly reduced in patients with RP and significantly correlated to BCVA and IS/OS integrity.

Subfoveal Choroidal Thickness Measured By Swept Source OCT in Retinitis Pigmentosa Patients