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After adventuring in the physiology and chemistry of respiration for more than forty years Professor Henderson pauses as he becomes emeritus to survey his career and to recount striking tales of combat and conquest. Many personal touches are preserved (e.g., p. 25) which are entirely lacking in the published abstracts of the encounters, but which are still vivid in the memories of those who took part in them. The pattern of the book follows the development of the author's varied interests, and his disputatious mood is manifested from the first paragraph of the introduction through to the concluding section of the last chapter. The early parts deal with the author's experiments on shock, acapnia, and the function of carbon dioxide in the respiratory and blood-vascular mechanisms. His unshakable conviction in the validity of his views, and the manner in which they were received by American physiologists led him early "to avoid theory and to aim rather at introducing these ideas in practical form directly into clinical use." (p. 19) In 191 1 the Pike's Peak expedition with Haldane, Douglas, and Schneider established the facts of alkalosis on ascent, acidosis on descent; and the experience supported his concept of a threshold of excitability of the respiratory center under the control of the supply of oxygen. These data were applied in the studies of the physiological conditions in high altitude flights and in the simulated altitudes of the Henderson rebreathing apparatus. The story of carbon monoxide asphyxia and the ventilation studies for the Holland Tunnel Commission are told in a fascinating manner spiced with personal experiences in the laboratory and in the field. From mine rescue apparatus to gas masks for military use, to the development of the H-H inhalator for resuscitation from asphyxia, was a rapid progress during the Great War and in the years immediately following. In the second half of the book the principles which the author had developed are applied to combatting neonatal asphyxia of respiratory, circulatory , or anesthetic origin. Studies on experimental pneumonia pointed the way to the use of carbon dioxide as a therapeutic agent in human cases of that disease. In conclusion, the author has turned again to the circulation, and especially to the factors which control the return of blood from the periphery to the heart, a mechanism which is of great importance in many cases of circulatory failure. The importance of skeletal …

Adventures in Respiration: Modes of Asphyxiation and Methods of Resuscitation