Open AccessApo and ligand-bound high resolution Cryo-EM structures of the human Kv3.1 channel reveal a novel binding site for positive modulators
Author(s) -
Mathieu Botte,
Sophie Huber,
Denis Bucher,
Julie K. Klint,
David Rodríguez,
Lena Tagmose,
Mohamed Chami,
R.K. Cheng,
Michael Hennig,
Wassim Abdul Rahman
Publication year - 2022
Publication title -
pnas nexus
Language(s) - English
Resource type - Journals
ISSN - 2752-6542
DOI - 10.1093/pnasnexus/pgac083
Subject(s) - drug discovery , ion channel , potassium channel , binding site , chemistry , biophysics , kcsa potassium channel , potentiator , docking (animal) , biology , biochemistry , genetics , receptor , medicine , nursing
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