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Methods: We performed a prospective open-label study in preterm infants admitted to 2 tertiary neonatal intensive care units. Each infant received a single dose of 30% sucrose intraorally during a 1to 2-minute period. A blood sample was obtained using an indwelling arterial catheter to determine -endorphin concentration immediately before and 2 to 5 minutes after the commencement of sucrose administration.

Beta-Endorphin Concentration after Administration of Sucrose in Preterm Infants