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For years researchers have struggled to identify etiologic factors that might explain the almost 10-fold differences in the incidence and mortality of prostate cancer between various geographic and ethnic populations. However little specific insights have been gained into identifying these etiologic factors or the mechanisms involved. Thus there is certainly a need to understand the limitations and advantages of new epidemiologic approaches and more specific molecular probes and how they can be applied more meaningfully. This special issue of the Epidemiologic Reviews publication contains 28 papers on important areas of study related to prostate cancer written by experts whose experience makes these papers most valuable. A most critical aim is to determine how these approaches will be integrated or fused to answer the bigger question of how to prevent or impact upon prostate cancer. Six questions and insights that might provide some direction toward finding clues to this mystery are given. Overall the papers in this issue should help some scientists to synthesize the proper studies needed to answer these questions.

New Insights and Methodologies Are Needed to Solve the Many Epidemiologic Enigmas of Prostate Cancer