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We read with great interest the paper by Bellini et al. (1997) regarding the usefulness of serum y-glutamyl transpeptidase isoforms (iso-GGT) in detecting alcoholic liver disease. The authors performed the separation of iso-GGT in sera from alcoholic patients (six affected by liver cirrhosis and 14 by fatty liver), compared to healthy and non-alcoholic liver disease-affected subjects (these latter included 43 patients with chronic hepatitis C, 36 patients with post-hepatitic cirrhosis and 52 epileptic patients). Since significant differences were found in iso-GGT among alcoholics and healthy subjects and patients with non-alcoholic liver disease, the authors proposed the iso-GGT fractionation as a complementary test in the diagnosis of alcoholic liver disease because of its high sensitivity.

CAN THE GAMMA-GLUTAMYL TRANSPEPTIDASE ISOFORMS REALLY BE UTILIZED IN THE DIAGNOSIS OF ALCOHOLIC LIVER DISEASE?