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Background The disease burden of seasonal influenza (flu) is high and contributes to morbidity, mortality and healthcare utilization. While only 1–2% of flu cases are hospitalized, these events are costly. The objective of this study was to describe and quantify risk factors for flu hospitalization. Methods Patients with 1 flu diagnosis (Dx) over 4 seasons (October 1, 2014–May 31, 2018) in IQVIA’s Real-World Data Adjudicated Claims – US database were selected into the study; the earliest flu Dx was the index date. Patients were required to have ≥12 months continuous enrollment in their health plan before index (baseline), ≥30 days after index, and either a record of a flu test ± 14 days of index or a flu Dx in the primary position. Comorbidities during a fixed 12-month baseline period were categorized by AHRQ and CDC definitions. The study outcome of interest, flu-related hospitalization during the 30-day follow-up period, was defined as hospitalization with Dx of flu or a pre-defined flu-related complication in any position. A logistic regression model assessed the odds of flu-related hospitalization, adjusting for age, sex, region, payer, season of index Dx, evidence of flu vaccination, and comorbidities. Results More than 1.6 million medically-attended flu cases were identified, of which 18,509 (1%) had a hospitalization. 40% of patients were &lt; 18 years of age, 47% were male, and 28%, 15%, 24%, and 33% were identified in the 2014–2017 flu seasons, respectively. More hospitalized patients were ages 50+ compared with non-hospitalized patients (57% vs. 20%) and 44% of hospitalized patients had 4 or more AHRQ/CDC comorbidities vs. 8% of non-hospitalized patients. In adjusted analyses, older age (65+ vs. 5–17; OR = 9.4, 95% CI 8.8–10.1) and leukemia/lymphoma/metastatic cancer (OR = 3.2, 95% CI = 2.9–3.5) were key drivers of hospitalization (Figure 1). Conclusion The risk of flu-related hospitalization is high for elderly populations and those with certain underlying co-morbidities among all age groups. While these findings reflect the burden of medically-attended flu in a younger, commercially insured population, additional research is needed to address the flu burden in high-risk populations. Disclosures All authors: No reported disclosures.

open forum infectious diseases

2758. Identifying Populations at High-Risk for Influenza-Related Hospitalization: A Real-World Analysis of Commercially Insured Population in the United States