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Background International travel can expose travelers to a number of health risks. Pre-travel consultation helps prepare travelers for health concerns that might arise. The assessment of risk, mitigation strategies, and relevance of pre-travel advice is dependent on whether travelers adhere to their planned travel itinerary and activities. Objectives. We aimed to determine the proportion of returned travelers whose actual travel itineraries differed from their planned travel plans (defined as discrepant trip experiences). We also aimed to identify traveler or trip characteristics associated with discrepant trip experiences. Methods We conducted a prospective cohort study at the Hospital for Sick Children’s Family Travel Medicine Clinic between September 2014 and December 2015. Pre- and post-trip questionnaires were compared with identify discrepant trip experiences. Results Among 186 participants, 121 (65%) reported their actual travel itineraries upon their return. A preliminary analysis of 53 participants revealed a median participant age of 37 years. Most common reasons for travel were vacation (n = 29, 55%) and visiting friends and/or relatives (n = 12, 23%). Median trip duration was 17 days (IQR 13 days); most commonly visited regions were Central America (n = 19, 36%), Asia (n = 18, 34%), and South America (n = 5, 9%). In total, 51 actual travel itineraries (96.2%, 95% CI 91–100) were discrepant from the pre-travel plans that were used to make pre-travel health recommendations. Additional activities (e.g., hiking, caving) (n = 42, 82.3%) and unplanned environments visited (e.g., altitude, jungle) (n = 32, 62.7%) during travel were the trip characteristics most likely to be discrepant. We did not identify any traveler demographic features or planned trip characteristics that predicted either discrepant trip experiences. Conclusion Based on our preliminary analysis, the majority of travelers reported discrepant trip experiences. We plan to complete the analysis of the full cohort (N = 121) and also to quantify if the discrepant features meaningfully altered health risks during travel. This study informs practitioners providing pre-travel consultation to consider broader counseling as discrepancies from planned travel are common. Disclosures All authors: No reported disclosures.

456. Discrepant Trip Experiences Among Travelers Attending a Tertiary Care Center Family Travel Medicine Clinic