English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Background Breast surgery is considered a clean surgery; however, surgical site infection (SSI) rates are higher than predicted. Postoperative drains remain in situ for several days with an inevitable bacterial colonization and increased risk of SSI. Methods We conducted a randomized controlled trial from October 2016 to January 2018 in a Mexican cancer center with high SSI prevalence. We included women with elective breast cancer surgery. Patients were randomized to control (standard drain care) or intervention (occlusive dressing with chlorhexidine 2% at the drain exit site). Perioperative management was standardized for both groups. Patient follow-ups were performed on a weekly basis for at least 30 days. Fluid cultures were performed at the first and second week as standardized in the laboratory. At the time of drain removal, the inner portion was sectioned and cultured by Maki’s semi-quantitative technique. Bacterial quantification was performed using 16 s rRNA-qPCR assay. Culture results of drain fluid and tubing were compared between groups. Results We included 104 patients with 167 surgical drains. Patients’ clinical characteristics (i.e., age, body mass index, comorbidities, clinical stage, preoperative risk, neoadjuvant therapy) were similar in both groups, with no statistical differences. Bulb fluid cultures at the first postoperative week were positive in 42.9% of the control group compared with 27.6% of the antiseptic group (P = 0.04). Cultures from the second week assessment were positive in 79.4% of the control group vs. 53.5% of the antiseptic arm (P = 0.001). Cultures from drain-tubes were positive in 70.2 and 43.8% (P = 0.001) of the control and antiseptic group, respectively (Figure 1). Eleven patients developed an SSI, three (15.4%) from the intervention group, and eight (15.8%) from the control group (P = 0.11). Eighty-four pathogens were isolated from the control group samples at week 1 vs. 52 from the intervention group. Staphylococci spp. were the most common microorganisms in Week 1, 61.9% control and 35% intervention group. Conclusion Local antiseptics provide an opportunity to test simple, safe, and low-cost interventions that may reduce drain bacterial colonization after breast surgery and potentially decrease infectious complications. Our microbiology findings question breast tissue sterility. Disclosures F. Rivera-Buendía, 3M: Donated the dressings used, Research support. D. Vilar-Compte, 3M: Donated the dressings used, Research support.

open forum infectious diseases

2122. Can Chlorhexidine Reduce Bacterial Colonization in Surgical Drains and Surgical Site Infections After Breast Cancer Surgery? A Randomized Controlled Trial