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Background Mechanical ventilation is a life-sustaining therapy for critically ill patients, but is associated with increased hospital costs and risk for significant complications with poor outcomes. Adverse ventilator-associated events (VAEs) can be broadly divided into infectious (infectious ventilator-associated complication (IVAC) or ventilator-associated pneumonia (VAP)) and non-infectious (ventilator-associated complication (VAC)) types. We sought to identify factors that predict both types, and factors that discriminate risk for infectious vs. noninfectious VAE, using electronic medical record (EMR) data available prior to index event. Methods We evaluated 90 consecutive adverse VAEs in the medical intensive care unit of an academic medical center (January 1, 2013–June 30, 2016) to determine prior patient and care factors that discriminate risk for incident VAE. VAE were defined by surveillance criteria from the CDC. Patient and care data were extracted via the EMR. Results A generalized linear mixed effects model found an increase of 1.1 (95% CI 0.53–1.7) subglottic suction events per day (SS/day) on the day before VAE diagnosis, relative to the 4 prior days. Of the 90 VAE included in the study, 41 were infectious (IVAC or VAP), and 49 were labeled ventilator-associated condition (VAC). In the IVAC/VAP group, mean SS/day was 8.0 on the day of VAE diagnosis, 7.5 one day prior, and 6.2 two days prior, compared with 6.6, 6.4, and 5.5 SS/day in the VAC group. Change in antibiotic prescription (87.8% (36) of patients in the IVAC/VAP group vs. 46.9% (23) in the VAC group) (P = 0.023) and acute liver injury (mean AST and ALT 52.9 and 43.6 3 days before IVAC/VAP vs. 1,035.4 and 523.9 before VAC) also differed between the groups (P = 0.0095 and 0.0025). Conclusion Increased daily subglottic suctioning predicts both non-infectious and infectious VAE, but the observed increase is greater prior to IVAC/VAP. Change in antibiotic prescription and acute liver injury also discriminated IVAC/VAP from non-infectious VAE in this small cohort. Disclosures All authors: No reported disclosures.

open forum infectious diseases

2105. Electronic Records of Daily Subglottic Suctioning Predict Infectious and Non-infectious Adverse Ventilator-Associated Events During Critical Care