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Background Environmental contamination plays an important role in the transmission of MRSA, VRE, and C. difficile. Suboptimal compliance with hand hygiene or inappropriate glove use can result in indirect transfer of these pathogens to patients. This study evaluates a novel disinfectant that claims to kill microbes on surfaces for ≥24 hours. Methods We investigated the persistent antimicrobial activity of a novel disinfectant using an EPA protocol for sustained disinfecting activity. In brief, surfaces are inoculated, treated with the novel disinfectant, allowed to dry, and then abraded using a standardized abrasion machine under multiple alternating wet and dry wipe conditions (N = 12) interspersed with 6 re-inoculations. After 24 hours, the surface was re-inoculated a final time and ability of the disinfectant to kill ≥99.9% of 9 test microbes within 5 minutes was measured on 3 test surfaces (glass, formica, and stainless steel). Results The novel disinfectant demonstrated a 3–5 log10 reduction in 5 minutes when testing S. aureus, VRE, C. auris, CRE E. coli and antibiotic-sensitive strains of E. coli, and Enterobacter sp. (table). The disinfectant demonstrated lower killing for CRE isolates of Enterobacter sp. and K. pneumoniae, and for antibiotic-sensitive K. pneumoniae (~2 log10 reduction in 5 minutes). When the novel disinfectant was compared with 3 other commonly used disinfectants using the same methodology with S. aureus, the mean log10 reductions were: 4.4 (novel disinfectant); 0.9 (quat-alcohol); 0.2 (improved hydrogen peroxide); and 0.1 (chlorine). Conclusion Persistent disinfectants may reduce or eliminate the problem of recontamination and minimize the role of environmental surfaces in transmission of healthcare pathogens.Table: Log10 Reduction of a Novel Disinfectant with Persistent Antimicrobial Activity Test Pathogen Mean log10 Reduction, 95% CI, n = 4 A S. aureus* 4.4 (3.9, 5.0) B S. aureus (formica) 4.1 (3.8, 4.4) C S. aureus (stainless steel) 5.5 (5.2, 5.9) D Vancomycin-resistant Enterococcus ≥4.5 E E. coli 4.8 (4.6, 5.0) F Enterobacter sp. 4.1 (3.5, 4.6) G Candida auris ≥5.0 H K. pneumoniae 1.5 (1.4, 1.6) I CRE E. coli 3.0 (2.6, 3.4) J CRE Enterobacter 2.0 (1.6, 2.4) K CRE K. pneumoniae 2.1 (1.8, 2.4) *Test surface is glass unless otherwise specified. Disclosures W. Rutala, PDI: Consultant and Speaker’s Bureau, Consulting fee and Speaker honorarium. D. Weber, PDI: Consultant, Consulting fee

1727. Sustained Antimicrobial Activity of a Novel Disinfectant Against Healthcare Pathogens