English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Background Differences in clinical characteristics and outcomes between community-acquired (CA) and healthcare-associated (HCA) Bacteroides bacteremia cases are not well known. Methods We evaluated all positive blood cultures between March 2012 and December 2016 in a Japanese 781-bed acute hospital. Identification and susceptibility was performed based on CLSI criteria, and MALDI-TOF has been used since January 2015 in addition to conventional methods. Results Of 3611 bacteremia cases, 266 (7.4%) were due to obligately anaerobic bacteria, such as Clostridium species (n = 97 [36.5%]), Fusobacterium species (15 [7.5%]), and Bacteroides species (65 [24.4%]), of which 31 (47.7%) were HCA and 34 (52.3%) were CA. In 22 (33.8%) cases, > 2 blood cultures were positive. B. fragilis was most frequently isolated (n = 25 [38.5%]), then B. thetaiotaomicron (n = 9 [13.8%]), B. vulgatus (n = 5, [7.7%]), B. uniformis (n = 3 [4.6%]), B. distasonis (n = 2 [3.1%]), B. ureolyticus (n = 2 [3.1%]), B. capillosus (n = 1 [1.5%]), and B. ovatus (n = 1 [1.5%]). After introducing MALDI-TOF, the number of unidentified Bacteroides species fell from 12 (18.5%) to 5 (7.7%). Sensitivity to ampicillin/sulbactam, cefmetazole, and clindamycin was 85.2%, 92.6%, and 59.3%, respectively. Most bacteremia (51 [78.5%]) were of intra-abdominal origin. Baseline characteristics and immunocompromised status of HCA and CA Bacteroides bacteremia patients were similar, except for diabetes, which was more frequent in HCA cases (Table). There was significantly higher 7- and 30-day mortality in HCA than in CA cases (P = 0.03). Conclusion The higher mortality in HCA Bacteroides bacteremia suggests the need for appropriate multidisciplinary management of these cases. Comparison of HCA vs. CA bacteremia episodes due to Bacteroides species CA (n = 31), n (%) HCA (n = 34), n (%) P-value Mean age (SD) 75.2 (11.6) 68.3 (17.5) 0.28 Male 22 (75.9) 27 (72.2) 0.78 Diabetes 3 (10) 13 (33.3) 0.04 Solid tumor 9 (31) 16 (45.7) 0.31 B. fragiles 8 (27.6) 15 (38.5) 0.20 B. thetaiotaomicron 5 (17.2) 4 (10.3) 0.88 7-day mortality 0 (0) 6 (16.7) 0.03 30-day mortality 2 (7.4) 11 (30.6) 0.03 Mean length of stay after bacteremia (SD) 35.7 (36.5) 40.1 (53.5) 0.33 Polymicrobial bacteremia 13 (44.8) 14 (37.8) 0.62 Disclosures All authors: No reported disclosures.

Comparison of Clinical Characteristics and Outcomes Between Community-Acquired and Healthcare-Associated Bacteremia Cases due to Bacteroides Species