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• Influenza is an important illness associated with significant morbidity, mortality and socioeconomic burden.1 • There is significant variation in severity of influenza infection, including among healthy individuals.1 • A standardized quantitative severity score that reflects the breadth of influenza complications would prove valuable in epidemiologic analyses of risk factors for severe influenza infection. • The maximum Comprehensive Severity Index score (maxCSI) is a composite, continuous measure of illness severity, based on the degree of abnormality of individual signs and symptoms of a patient’s disease or diseases.2 • The Comprehensive Severity Index contains matrices of age-specific criteria for influenza as well as related complications.2

An Assessment of the Validity of the Comprehensive Severity Index (CSI) as a Measure of Severity of Influenza Infection in Children