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Background • Antibiotic exposure in the intestinal tract is the most important risk factor for Clostridium difficile infection (CDI) • Oral administration of beta-lactamase enzymes such as SYN-004 (Synthetic Biologics, Inc) has been effective in eliminating the portion of intravenous beta-lactam antibiotics excreted into the intestinal tract, preserving the microbiota during therapy • We examined patterns of use of beta-lactams and the relative frequency of healthcare facilityassociated (HCFA)-CDI associated with them given alone or combined with other antibiotics

open forum infectious diseases

Healthcare Facility-Associated Clostridium difficile Infection in Hospitalized Patients Receiving Intravenous Beta-Lactam Antibiotics in the Veterans Affairs Healthcare System (VHA)