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Francine Kwee, BScH, BScPhm, ACPR Elizabeth Leung, Pharm D, BCPS AQ-ID Clinical Pharmacist – Nephrology/Urology Clinical Pharmacy Specialist – Infectious Diseases/ASP E-mail: kweef@smh.ca E-mail: leungeli@smh.ca Aminoglycoside Dosing • Pharmacokinetic (PK) literature in intermittent hemodialysis (iHD) is outdated current practice employs more efficient iHD modalities. • Efficacy is obtained by maximizing the peak serum concentration (Cmax) to minimum inhibitory concentration (MIC) ratio. • Toxicity (nephrotoxicity) is thought to be related to body exposure as measured by the area under the serum concentration versus time curve (AUC).

open forum infectious diseases

Pharmacokinetics of Intravenous Amikacin in Intermittent Hemodialysis: Treatment of Peritoneal Dialysis Peritonitis Caused by Nontuberculous Mycobacterium (NTM)