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Methods  Adult and pediatric drug use data were obtained from the Truven Health MarketScan® Hospital Drug Database (HDD).  The HDD contains hospital discharge records for all patients discharged from participating US hospitals.  Includes discharge-specific diagnostic codes, demographic information, inpatient drug utilization data based on billing records, admission and discharge dates, and facility descriptors.  Included visits from January 1, 2006 through December 31, 2012.  For each discharge, we identified antifungal doses (oral, parental, and inhalation routes only) charged to the patient during the inpatient stay.  Antifungal use calculated as days of therapy (DOT) / 1,000 patient days (PDs)  Extrapolated national estimates of inpatient antifungal use using data submitted to the Centers for Medicare and Medicaid Services Healthcare Cost Report Information System (HCRIS).  Assessed trends in antifungal use by year using a linear regression multivariable model (outcome distribution was approximately normal)  Used generalized estimating equations (GEE) to account for interhospital covariance.  Included as covariates facility characteristics such as case mix index (a marker of overall disease severity), average patient age, bed size category, teaching status, urban or rural location, proportion of surgical discharges, average co-morbidity score for the facility, and geographic region (by US Census division). Results

National Estimates of Antifungal Use Among Inpatients Based on Administrative Data─United States, 2006–2012.