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• Epidemiology of pneumococcal infection is changing rapidly after introduction of pneumococcal conjugate vaccine. • Pneumonia with empyema and/or bacteremia, febrile bacteremia and meningitis are the commonest manifestations of invasive pneumococcal disease (IPD). • The incidence of IPD has been unknown for decades in Korea. • This study was done to estimate the incidence rate of IPD and to describe the change of burden after introduction of the vaccine in Korea.

Changes of Invasive Pneumococcal Disease Burden in Korea, 2005–2014: Analysis of the National Health Insurance Database