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Background: Airborne transmission of pathogens such as Mycobacterium tuberculosis can result in the rapid spread of disease. This project assessed the ability of PhotoxAir, a novel mobile air purification system (MAPS) based on photocatalytic oxidation, to minimize the bacterial air burden during routine patient care in an emergency department (ED). Methods: Fifty patients admitted to the ED underwent air sampling in their respective rooms during routine care activities. One six-stage Andersen Air Sampler each was placed at the head and foot of a patient’s bed and at the exit/entrance doorway. The MAPS was positioned near the foot of the bed. All samples were collected on blood agar plates. Baseline air burden was assessed for 20 minutes without MAPS activated, followed by a wash-out phase with MAPS activated (eight total air exchanges per room), and a 20 minute air sampling with MAPS activated. Colony-forming units (CFUs) were counted and summed for each location. Significance was assessed using the signed Wilcoxon rank-sum test. Results: A significant reduction in bacterial CFUs was observed from baseline to MAPS use. The greatest decrease was seen at the head of the bed (-7 CFUs; -54%; p<0.001) followed by the foot of the bed (-4.5 CFUs; 47%; p<0.001) and the exit (-3.5 CFUs; -27%; p<0.001). The room total (sum across all sampling locations) also showed a significant reduction (-15 CFUs; -46%; p<0.001) under MAPS use. Conclusions: The MAPS significantly reduced the bacterial load observed under routine care in an ED setting. The foot of the bed and the exit showed smaller decreases probably affected by higher traffic/activity patterns in these areas as compared to the head of the bed. Application of this new, mobile technology promises to reduce the airborne pathogen burden, and decrease exposure risk providing a safer environment for patient care.

1375Reduction of Bacterial Air Burden During Routine Patient Care by a Novel Mobile Air Purification System (PhotoxAir)