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We performed a prospective cohort study enrolling patients admitted to newly-disinfected hospital rooms at a tertiary care medical center and a community hospital. Samples from patients and room surfaces were cultured and analyzed to describe the level of colonization of 4 MDROs (MRSA, VRE, MDR Acinetobacter and C. difficile [Cdiff]) at scheduled intervals during hospitalization in the same room (day of enrollment, day 3, day 7, weekly thereafter, and on discharge). Rodac plates were used to sample 8 specific surfaces in patient rooms using previously-published methods. Patient specimens were collected from anterior nares, pharynx, axillae, rectum, and if available, from wounds, indwelling devices and feces.

open forum infectious diseases

1367A Prospective Longitudinal Study of Transmission of Multidrug Resistant Organisms (MDROs) between Environmental Sites and Hospitalized Patients – Interim Analysis of the TransFER Study