218. A 5-Year Retrospective Study of Actinomyces Odontolyticus Bacteraemia

Background Actinomyces species are Gram positive anaerobic, non-sporulating, non-acid fast, non-motile, irregularly staining bacterium. It is associated with a wide range of infections including; dental caries, abscesses, intraabdominal and bloodstream infections. A. odontolyticus normally a commensal organism found in the mouth, was first isolated from dental caries in 1958. The incidence of Actinomyces odontolyticus bacteremia is less common. Methods We are reporting 15 cases of isolated A. odontolyticus blood stream infection at HMC, State of Qatar from 1/1/2016 to 1/11/2020. We aim to describe their clinical characteristic, risk factors and treatment outcome. Results Our patients with bacteraemia fall into one of two groups. The first group consists of paediatric patients with unremarkable co-morbidities. The second group includes older adults, often with co-morbidities that pre-dispose to infection, such as diabetes mellitus or hypertension. Fever was the main presenting sign and symptom in 12 patients (80%). Nine of the patients were females (60%). 13 patients (86%) received antibiotics. Maximum duration of antibiotics was 60 days and minimum duration was three days. The infectious disease team was consulted for six patients (40%). One patient died while the other 14 recovered uneventfully with a case fatality rate of 6.6%. Reported cases of Actinomyces odontolyticus bacteraemia in Hamad Medical Corporation between 1/1/2016 to 1/11/2020Minimal inhibitory concentrations (MICs) of selected antibiotics against A. odontolyticus, including interpretations and breakpoints, as reported by the AMRHAI reference unit, PHE ColindaleConclusion Clinicians of all specialties need to be aware of the rising number of reports of Actinomyces species bacteraemia due to widespread availability of molecular identification techniques, including MALTI-TOF. 3 Furthermore, more studies are needed to determine guidelines for treating these resilient microbes Disclosures All Authors : No reported disclosures