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Background  Given the limited collaborative international studies that evaluated COVID-19 in patients with cancer in comparison to patients without cancer, we aimed to determine the independent risk factors associated with increased 30-day mortality and the impact of novel treatment modalities in a large group of cancer and non-cancer patients with COVID-19 from multiple countries.    Methods  We retrospectively collected de-identified data on cancer and non-cancer patients diagnosed with COVID-19 between January and November 2020, at 16 centers in Asia, Australia, Europe, North America, and South America. A logistic regression model was used to identify independent predictors of all-cause mortality within 30 days after COVID-19 diagnosis.    Results  Of the total 4015 COVID-19 confirmed patients entered, we analyzed 3966 patients, 1115 cancer and 2851 non-cancer patients. Cancer patients were older than non-cancer patients (median age, 61 vs 50 years; p< 0.0001); more likely to be pancytopenic , had pulmonary disorders, hypertension, diabetes mellitus. In addition, they were more likely to present with higher inflammatory biomarkers (D-dimer, ferritin and procalcitonin), but were less likely to present with clinical symptoms. By multivariable logistic regression analysis, cancer was an independent risk factor for 30-day mortality (OR 1.46; 95% CI 1.03 to 2.07; p=0.035). Older age (≥65 years) was the strongest predictor of 30-day mortality in all patients (OR 4.55; 95% CI 3.34 to 6.20; p< 0.0001). Remdesivir was the only therapeutic agent independently associated with decreased 30-day mortality (OR 0.58; CI 0.39-0.88; p=0.009). Among patients on low-flow oxygen at admission, patients who received remdesivir had a lower 30-day mortality rate than those who were on high flow oxygen (5.9% vs 17.6%; p=0.03). Patients transfused with convalescent plasma within 1 day of diagnosis had a lower 30-day mortality rate than those transfused later (1% vs 7%,  p =0.04).    Conclusion  Cancer is an independent risk factor for increased 30-day all-cause mortality from COVID-19. Remdesivir, particularly in patients receiving low-flow oxygen, can reduce 30-day all-cause mortality, as well as convalescent plasma given early after COVID-19 diagnosis.    Disclosures    Roy F. Chemaly, MD, MPH, FACP, FIDSA ,  AiCuris  (Grant/Research Support) Ansun Biopharma  (Consultant, Grant/Research Support) Chimerix  (Consultant, Grant/Research Support) Clinigen  (Consultant) Genentech  (Consultant, Grant/Research Support) Janssen  (Consultant, Grant/Research Support) Karius  (Grant/Research Support) Merck  (Consultant, Grant/Research Support) Molecular Partners  (Consultant, Advisor or Review Panel member) Novartis  (Grant/Research Support) Oxford Immunotec  (Consultant, Grant/Research Support) Partner Therapeutics  (Consultant) Pulmotec  (Consultant, Grant/Research Support) Shire/Takeda  (Consultant, Grant/Research Support) Viracor  (Grant/Research Support) Xenex  (Grant/Research Support)  Fareed Khawaja, MBBS ,  Eurofins Viracor  (Research Grant or Support)  Monica Slavin, MBBS,MD ,  F2G  (Advisor or Review Panel member) Merck  (Advisor or Review Panel member) Pfizer  (Advisor or Review Panel member)  Dimitrios P. Kontoyiannis, MD ,  Astellas  (Consultant) Cidara Therapeutics  (Advisor or Review Panel member) Gilead Sciences  (Consultant, Grant/Research Support, Other Financial or Material Support, Honoraria)

22. International Multicenter Study Comparing Cancer to Non-Cancer Patients with COVID-19: Impact of Risk Factors and Treatment Modalities on Outcome