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The current study examined whether the presence of the G allele of the A118G polymorphism of the OPRM1 gene (rs1799971) and the long allele of exon 3 VNTR polymorphism of the DRD4 gene moderate the effect of alcohol administration on urge to smoke. These polymorphisms have been associated with greater alcohol induced-urge to drink. Urge to drink and alcohol consumption increase urge to smoke. Therefore, these polymorphisms may also sensitize urge to smoke after alcohol consumption.

nicotine and tobacco research

Influence of the A118G Polymorphism of the<i>OPRM1</i>Gene and Exon 3 VNTR Polymorphism of the<i>DRD4</i>Gene on Cigarette Craving After Alcohol Administration

Influence of the A118G Polymorphism of theOPRM1Gene and Exon 3 VNTR Polymorphism of theDRD4Gene on Cigarette Craving After Alcohol Administration