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Large-scale epidemiological surveys have frequently relied upon clinic-based sample collection to incorporate biological data, which can be costly and result in nonrepresentative data. Collecting samples in a nonclinical setting (i.e., through postal mail or at the subject's home) offers an alternative option that is minimally invasive and can be incorporated into large population-based studies.

ITC “spit and butts” pilot study: The feasibility of collecting saliva and cigarette butt samples from smokers to evaluate policy