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Background Childhood cerebellar pilocytic astrocytomas harbour excellent overall survival rates after surgical resection, but the patients may exhibit specific cognitive and behavioural problems. Functional MRI has catalysed insights into brain functional systems and has already been linked with the neuropsychological performance. We aimed to exploit the question whether resting-state functional MRI can be used as a biomarker for the cognitive outcome assessment of these patients. Methods We investigated 13 patients (median age 22.0 years, range 14.9 – 31.3) after a median interval between surgery and examination of 15.0 years (range 4.2 – 20.5) and 16 matched controls. All subjects underwent a functional 3T MRI scans in a resting state condition and a battery neuropsychological tests. Results Patients showed a significantly increased functional connectivity in the precuneus compared to controls (p&amp;lt;0.05) and at the same time impairments in various domains of neuropsychological functioning such as a lower mean WIE IQ percentile (M = 48.62, SD = 29.14), lower scores in the TMT letter sequencing (M = 49.54, SD = 30.66), worse performance on the WIE subtest Digit Symbol Coding (M = 38.92, SD = 35.29), subtest Symbol Search (M = 40.75, SD = 35,28), and TAP divided attention task (M = 783.92, SD = 73.20). Conclusion Childhood cerebellar tumor treated by resection only strongly impacts on the development of precuneus/PCC functional connectivity. Functional MRI has the potential to help deciphering the pathophysiology of cerebellar-related cognitive impairments in these patients and could be an additional tool in their individual assessment and follow-up.

Impact of childhood cerebellar tumor surgery on cognition revealed by precuneus hyperconnectivity