Open AccessGEN-09 Pursuing the function of microRNA targeting (Pro)renin receptor against glioma
Author(s) -
Daisuke Ogawa,
Takeshi Fujimori,
Yasunori Toyota,
Tetsuhiro Hatakeyama,
Masanobu Okauchi,
Masahiko Kawanishi,
Keisuke Miyake,
Tsutomu Masaki,
Akira Nishiyama,
Takashi Tamiya
Publication year - 2020
Publication title -
neuro-oncology advances
Language(s) - English
Resource type - Journals
ISSN - 2632-2498
DOI - 10.1093/noajnl/vdaa143.021
Subject(s) - wnt signaling pathway , microrna , glioma , cancer research , biology , stem cell , signal transduction , receptor , microbiology and biotechnology , gene , genetics
(Pro)renin receptor((P)RR) is a part of the Wnt receptor complex. Wnt/β-catenin signaling pathway (Wnt signaling) plays important role in pathogenesis and self-renewal of glioblastoma (GBM), or differentiation of glioma stem cell. We previously reported that (P)RR activated Wnt signaling, (P)RR expression correlated with malignancy of glioma, and treatment with (P)RR siRNA reduced the proliferative capacity. This time, we have searched for over 2632 microRNAs by microRNA microarray that its expression is affected by (P)RR whether overexpressed or suppressed and examined their effects in GBM cell lines or its glioma stem cells.
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