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8:35am – 8:55am The blood-brain barrier and its effect on drug delivery to brain and tumor Quentin Smith, Texas Tech University 8:55am – 9:15am Factors influencing the distribution of free drug to tumors in the CNS William Elmquist, University of Minnesota 9:15am – 9:30am Understanding brain penetrance of anticancer agents for infiltrative gliomas Victor Levin, Levin Consulting 9:30am – 9:45am Development of a translational PK model for characterizing and predicting protein therapeutics in the brain Dhaval K. Shah, University of Buffalo

CADD-03. A VERSATILE AND MODULAR TARGETED NANOPARTICLE PLATFORM FOR DELIVERY OF COMBINATION THERAPIES TO ADULT AND PEDIATRIC CNS TUMORS