Open AccessAn oncolytic measles virus–sensitive Group 3 medulloblastoma model in immune-competent mice
Author(s) -
Sangeet Lal,
Diego Carrera,
Joanna J. Phillips,
William A. Weiss,
Corey Raffel
Publication year - 2018
Publication title -
neuro-oncology
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 4.005
H-Index - 125
eISSN - 1523-5866
pISSN - 1522-8517
DOI - 10.1093/neuonc/noy089
Subject(s) - oncolytic virus , medulloblastoma , measles virus , immune system , cancer research , biology , virology , immunology , measles , vaccination
Oncolytic measles virus (MV) is effective in xenograft models of many tumor types in immune-compromised mice. However, no murine cell line exists that is tumorigenic, grows in immune-competent mice, and is killed by MV. The lack of such a model prevents an examination of the effect of the immune system on MV oncotherapy.
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