Meningioma transcription factors link cell lineage with systemic metabolic cues | Zendy

Ziming Du | Zendy; Ryan Brewster | Zendy; Parker Merrill | Zendy; Juliann Chmielecki | Zendy; Josh Francis | Zendy; Ayal A. Aizer | Zendy; Malak Abedalthagafi | Zendy; Lynette M. Sholl | Zendy; Lars Geffers | Zendy; Brian M. Alexander | Zendy; Sandro Santagata | Zendy

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Meningioma transcription factors link cell lineage with systemic metabolic cues

Author(s) -

Ziming Du,

Ryan Brewster,

Parker Merrill,

Juliann Chmielecki,

Josh Francis,

Ayal A. Aizer,

Malak Abedalthagafi,

Lynette M. Sholl,

Lars Geffers,

Brian M. Alexander,

Sandro Santagata

Publication year - 2018

Publication title -

neuro-oncology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 4.005

H-Index - 125

eISSN - 1523-5866

pISSN - 1522-8517

DOI - 10.1093/neuonc/noy057

Subject(s) - transcription factor , meningioma , link (geometry) , biology , transcription (linguistics) , lineage (genetic) , genetics , microbiology and biotechnology , computational biology , gene , medicine , pathology , computer science , computer network , linguistics , philosophy

Tumor cells recapitulate cell-lineage transcriptional programs that are characteristic of normal tissues from which they arise. It is unclear why such lineage programs are fatefully maintained in tumors and if they contribute to cell proliferation and viability.

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