Open AccessDivergent evolution of temozolomide resistance in glioblastoma stem cells is reflected in extracellular vesicles and coupled with radiosensitization
Author(s) -
Delphine Garnier,
Brian Meehan,
Thomas Kislinger,
Paul Daniel,
Ankit Sinha,
Bassam Abdulkarim,
Ichiro Nakano,
Janusz Rak
Publication year - 2017
Publication title -
neuro-oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.005
H-Index - 125
eISSN - 1523-5866
pISSN - 1522-8517
DOI - 10.1093/neuonc/nox142
Subject(s) - temozolomide , extracellular vesicles , glioblastoma , cancer research , microvesicles , stem cell , extracellular , vesicle , resistance (ecology) , radiation tolerance , chemistry , biology , microbiology and biotechnology , medicine , radiation therapy , gene , biochemistry , microrna , ecology , membrane
Glioblastoma (GBM) is almost invariably fatal due to failure of standard therapy. The relapse of GBM following surgery, radiation, and systemic temozolomide (TMZ) is attributed to the ability of glioma stem cells (GSCs) to survive, evolve, and repopulate the tumor mass, events on which therapy exerts a poorly understood influence.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom