Open AccessReactive astrocytes potentiate tumor aggressiveness in a murine glioma resection and recurrence model
Author(s) -
Onyinyechukwu Okolie,
Juli R. Bagó,
Ralf S. Schmid,
David Irvin,
Ryan Bash,
C. Ryan Miller,
Shawn Hingtgen
Publication year - 2016
Publication title -
neuro-oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.005
H-Index - 125
eISSN - 1523-5866
pISSN - 1522-8517
DOI - 10.1093/neuonc/now117
Subject(s) - glioma , tumor microenvironment , astrocyte , cancer research , immunostaining , glial fibrillary acidic protein , pathology , nestin , immune system , medicine , immunohistochemistry , tumor progression , transcriptome , biology , cancer , immunology , central nervous system , microbiology and biotechnology , gene expression , neural stem cell , stem cell , gene , biochemistry
Surgical resection is a universal component of glioma therapy. Little is known about the postoperative microenvironment due to limited preclinical models. Thus, we sought to develop a glioma resection and recurrence model in syngeneic immune-competent mice to understand how surgical resection influences tumor biology and the local microenvironment.
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