Open AccessMicroRNA-128 coordinately targets Polycomb Repressor Complexes in glioma stem cells
Author(s) -
Pierpaolo Peruzzi,
Agnieszka Bronisz,
Michal O. Nowicki,
Yan Wang,
Daisuke Ogawa,
Richard L. Price,
Ichiro Nakano,
Chang-Hyuk Kwon,
Josie Hayes,
Sean Lawler,
Michael C. Ostrowski,
E. Antonio Chiocca,
Jakub Godlewski
Publication year - 2013
Publication title -
neuro-oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.005
H-Index - 125
eISSN - 1523-5866
pISSN - 1522-8517
DOI - 10.1093/neuonc/not055
Subject(s) - bmi1 , gene knockdown , radioresistance , biology , glioma , neural stem cell , cancer research , stem cell , microrna , cancer stem cell , prc2 , microbiology and biotechnology , epigenetics , cell culture , ezh2 , gene , genetics
The Polycomb Repressor Complex (PRC) is an epigenetic regulator of transcription whose action is mediated by 2 protein complexes, PRC1 and PRC2. PRC is oncogenic in glioblastoma, where it is involved in cancer stem cell maintenance and radioresistance.
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