Open AccessMolecular interactions of ErbB1 (EGFR) and integrin- 1 in astrocytoma frozen sections predict clinical outcome and correlate with Akt-mediated in vitro radioresistance
Author(s) -
Marek Petráš,
Tamás Lajtos,
E. Friedlander,
Álmos Klekner,
Éva Pintye,
Burt G. Feuerstein,
János Szöllõsi,
György Vereb
Publication year - 2013
Publication title -
neuro-oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.005
H-Index - 125
eISSN - 1523-5866
pISSN - 1522-8517
DOI - 10.1093/neuonc/not046
Subject(s) - radioresistance , cancer research , integrin , biology , protein kinase b , pathology , receptor , signal transduction , medicine , cell culture , microbiology and biotechnology , biochemistry , genetics
Treatment of astrocytoma is frequently hampered by radioresistance of the tumor. In addition to overexpression of ErbB1/EGFR, functional crosstalk between receptor tyrosine kinases and cell adhesion molecules may also contribute to therapy resistance.
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