English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

BACKGROUND/OBJECTIVES We have previously shown that delayed-contrast-MRI-based TRAMs enable efficient separation between tumor and treatment-effects, validated histologically, reaching 100%/93% sensitivity/PPV to active tumor. Proton beam therapy (PBT) is a highly conformal radiotherapy modality with increasing use in CNS tumors. Here, for the first time, we studied the application of standard MRI and TRAMs for monitoring patients during/following PBT. METHODS 8 patients with gliomas (4 grade II, 3 grade III, 1 grade IV) and 9 with meningiomas (6 grade 1, 2 grade II, 1 grade III) were scanned by standard MRI and TRAMs at baseline, mid-term during PBT (treatment duration 22-30 days), end of treatment and 6/12 months thereafter. Enhancing volumes (EVs) were calculated from contrast-enhanced MRI, while blue/tumor and red/radiation-changes volumes (blueV/redVs) were calculated from the TRAMs. RESULTS Three gliomas showed increased (by &amp;gt; 10%) EVs (15.2±8.7%), 3 stable and 2 decreased EVs (14.2±8.5%) during treatment. At the end of treatment 3 showed increased volumes (27.6±10.4%) and 5 decreased volumes (26.4±6.5%). One meningioma showed decreased EVs (11%) while 8 were stable during treatment. At end of treatment one showed increased EVs (22%), 5 were stable and 3 showed increased EVs (13.7±1.7%). The TRAMs showed similar trends but of varied magnitudes. In addition, the TRAMs could indicate radiation changes in two cases with increased enhancement: One glioma showed increased EVs/redVs and decreased blueVs during treatment, consistent with pseudoprogression, confirmed later by significant shrinkage of all volumes, and one meningioma with a similar pattern at 6 months. CONCLUSIONS Our initial results show for the first time significant changes in brain tumors volumes, during and at the end of PBT. The addition of TRAMs may suggest a new tool to assess PBT radiation effects. Interpretation of these results, comparison between tumor types/grades, and correlation with treatment planning and additional follow-up will be presented.

neuro-oncology

NIMG-63. THE APPLICATION OF MRI AND TREATMENT RESPONSE ASSESSMENT MAPS (TRAMS) FOR MONITORING TREATMENT EFFECTS DURING/FOLLOWING PROTON BEAM THERAPY – INITIAL EXPERIENCE