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AND AIMS: There are many studies which showed the effects of phosphate binders on the progression of vascular calcification. We have recently reported that lanthanum carbonate, a non-calcium-containing phosphate binder has a less effect on the progression of coronary artery calcification compared to calcium carbonate, a calcium-containing phosphate binder. It is generally thought that mineral disorder such as hypercalcemia and/or hyperphosphatemia have an influence on not only vascular calcification but also cardiac valvular calcification (CVC); however, there is only a few previous studies regarding the effects of phosphate binders on CVC after initiation of maintenance hemodialysis. The aim of the present study was to compare the effects of lanthanum carbonate with those of calcium carbonate on the progression of CVC in patients who initiated maintenance hemodialysis.

nephrology, dialysis, transplantation/nephrology dialysis transplantation

SP548COMPARISON OF THE EFFECTS OF LANTHANUM CARBONATE AND CALCIUM CARBONATE ON THE PROGRESSION OF VALVULAR CALCIFICATION AFTER INITIATION OF MAINTENANCE HEMODIALYSIS