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METHODS: We therefore studied nicotinamide and magnesium carbonate (MC) as phosphate modulators/-binder in a mouse model of CKD and in in vitro cell culture of human vascular smooth muscle cells and murine Gli1þ progenitor cells. DBA/2 mice underwent 5/6 nephrectomy and were treated for 7 weeks with nicotinamide, magnesium carbonate or a combination of both. In vitro, calcifying cells were treated in the same way.

SP406MAGNESIUM AND NICOTINAMIDE: COMPLEMENTARY STRATEGIES AGAINST CALCIFICATION IN EXPERIMENTAL UREMIA