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AND AIMS: Chronic kidney disease (CKD) has been associated with increased cardiovascular risk. Conventional echocardiographic indices and novel 2D speckle tracking (2DST), deformation related indices, are considered to be a suitable diagnostic utility for the evaluation of subclinical left ventricular (LV) dysfunction and may discriminate patients at high cardiovascular related risk. The aim of the study was to identify differences between CKD patients and healthy controls, using classical and novel 2DST echocardiographic indices, after dypiridamole infusion. METHODS: Thirty CKD patients (mean eGFR 34.7617.6ml/min/1.73m,urine protein median value 1010 mg/24hr, mean age 54 years old, 70% men), in steady state from the outpatient clinic and 15 age and gender matched healthy controls (mean age 50 years old, 67% men) were included in this prospective study. Exclusion criterion was known cardiovascular disease. LV systolic and diastolic function indices (by conventional tissue Doppler and 2DST echocardiography) were assessed at baseline and after administration of dipyridamole in all subjects. Coronary flow reserve (CFR), on LAD was also assessed. RESULTS: CKD patients had higher MPI (0.5560.13 vs 0.4460.15) and E/E’ (7.762.1 vs 6.161.5) values (p<0.05 for all) compared to controls. CFR values after dipyridamole administration were lower in CKD compared to controls [median value 3.3 (2.5, 3.5) vs 3.9 (3.0, 4.5), p1⁄40.037]. Dipyridamole use caused an increase in E and A wave, MAPSE septal and lateral and a decrease in global longitudinal and global circumferential strain in both CKD patients and controls (p<0.05 for all). On the other hand E/A, MPI, E/Vp and time to untwist were decreased only in CKD patients while DecT was decreased only in controls (p<0.05 for all) after dipyridamole administration. Only dipyridamole-induced changes in DecT were different between CKD and controls (p1⁄40.039).

nephrology, dialysis, transplantation/nephrology dialysis transplantation

SP254EVALUATION OF CLASSICAL AND NOVEL 2D STRAIN ECHOCARDIOGRAPHIC INDICES BEFORE AND AFTER DIPYRIDAMOLE INFUSION, IN PATIENTS WITH CHRONIC KIDNEY DISEASE COMPARING TO HEALTHY CONTROLS