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AND AIMS: Nowadays, high-flux membranes represent the standard treatment in bicarbonate hemodialysis (HD). Despite of the undeniable benefits in clearance compared to low-flux membranes, their capability in clearance of medium molecules remains poor, especially compared to online hemodiafiltration (HDF), a treatment however not available for clinical reasons in all patients. Recently, became available in Italian market the TheranovaVR 400, defined as first medium cut-off membrane for a significant clearance of molecules under 45 kDa without inducing any reliable loss of albumin. The purpose is to reach a clearance of medium molecules during bicarbonate HD comparable to an online HDF. In this study we evaluated the reduction ratio (RR) of myoglobin (17kDa) in a sample of our patients chronically treated with their common hemodialysis membranes and then with new medium cut-off membrane comparing them with patients treated with online HDF.

FP466NEW MEDIUM CUT-OFF MEMBRANE VS ONLINE HEMODIAFILTRATION IN CLEARANCE OF MIDDLE MOLECULES. PRELIMINARY RESULTS FROM OUR CENTRE