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Methods: A single center, open-label, randomized, controlled study was conducted. Patients with hyponatremia (serum Na <130 mmol/L) due to SIAD were randomly assigned to one of the following groups: 1) fluid restriction alone (FR, n=32), 2) fluid restriction and furosemide (FR+FM, n=30), and 3) fluid restriction, furosemide, and NaCl tablets (FR+FM+NaCl, n=31). Daily fluid restrictions were <0.5 L or <1 L depending on free-water clearance. Furosemide dosage was 20-40 mg once daily and NaCl supplement was 3 gm daily. All treatments were continued until 28 days. The primary end point was serum Na level on day 4 after randomization. The secondary end points were serum Na on day 7 and day 28 after randomization, percentage of patients achieving serum Na of ≥130 or ≥135 mmol/L at day 4 after randomization, and time to achieve serum Na of ≥130 and ≥135 mmol/L.

nephrology, dialysis, transplantation/nephrology dialysis transplantation

FP125THE EFFICACY OF FUROSEMIDE, SALT TABLETS, AND FLUID RESTRICTION FOR TREATMENT OF PATIENTS WITH SYNDROME OF INAPPROPRIATE ANTIDIURESIS: AN OPEN-LABEL, RANDOMIZED, CONTROLLED STUDY (EFFUSE-FLUID TRIAL)