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Purpose Obesity (defined as body mass index [BMI] ≥30 kg/m) is common in patients with chronic kidney disease (CKD). Activation of the renin-angiotensin-aldosterone system may play a causative role in in the development of CKD in obesity along with other factors such as proteinuria and hypertension. Renin-angiotensin-aldosterone system inhibitors (RAASi) are effective in CKD or heart failure patients, with or without obesity. The risk of hyperkalemia in CKD or heart failure treated with RAASi, including aldosterone antagonists, is similar in obese and non-obese patients. Patiromer, a nonabsorbed, sodium-free, potassium binder, has been shown to effectively reduce serum potassium levels in hyperkalemic patients with CKD taking RAASi. The effect of patiromer in obese patients with hyperkalemia and CKD has not been previously reported.

nephrology, dialysis, transplantation/nephrology dialysis transplantation

FP102EFFECT OF PATIROMER ON SERUM POTASSIUM IN HYPERKALAEMIC PATIENTS WITH AND WITHOUT OBESITY: POOLED RESULTS FROM THE AMETHYST-DN, OPAL-HK AND TOURMALINE TRIALS