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CONCLUSIONS: Our study, revealed, for the first time, a specific metabolic profile associated to MSK and confirmed our previous published evidences that this cystic disease could be characterized by additional systemic biochemical alterations (including mitochondrial dysfunction and alterations of the sphingomyelin metabolism). Finally, in future, some identified metabolic factors could represent new diagnostic biomarkers employable in the “day by day” clinical practice.

FP058LEVELS OF ENDOCAN, ANGIOPOIETIN-2 AND HIF-1A IN PATIENTS WITH AUTOSOMAL DOMINANT POLYCYSTIC KIDNEY DISEASE AND DIFFERENT LEVELS OF RENAL FUNCTION