Open AccessUrinary and serum soluble CD25 complements urinary soluble CD163 to detect active renal anti-neutrophil cytoplasmic autoantibody-associated vasculitis: a cohort study
Author(s) -
Gerjan J. Dekkema,
Wayel H. Abdulahad,
Theo Bijma,
Sarah Moran,
Louise Ryan,
Mark A. Little,
Coen A. Stegeman,
Peter Heeringa,
JanStephan Sanders
Publication year - 2018
Publication title -
nephrology dialysis transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.654
H-Index - 168
eISSN - 1460-2385
pISSN - 0931-0509
DOI - 10.1093/ndt/gfy018
Subject(s) - medicine , autoantibody , vasculitis , urinary system , gastroenterology , creatinine , immunology , biomarker , pathology , disease , antibody , biology , biochemistry
Early detection of renal involvement in anti-neutrophil cytoplasmic autoantibody (ANCA)-associated vasculitis (AAV) is of major clinical importance to allow prompt initiation of treatment and limit renal damage. Urinary soluble cluster of differentiation 163 (usCD163) has recently been identified as a potential biomarker for active renal vasculitis. However, a significant number of patients with active renal vasculitis test negative using usCD163. We therefore studied whether soluble CD25 (sCD25), a T cell activation marker, could improve the detection of renal flares in AAV.
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