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A number of conditions in pregnancy present with microangiopathic hemolytic anemia and thrombocytopenia (MAHAT), including HELLP-syndrome. Recent evidence and clinical similarities suggest a link to P-aHUS, a disease of excessive activation of the alternative complement pathway. HELLP syndrome (hemolysis, elevated liver enzymes, and low platelets) is a severe variant of PE that leads to severe morbidity and mortality to both the mother and fetus. Delivery is the treatment of choice of PE and HELLP, but can lead to progression in case of aHUS. Recent studies suggest that HELLP-syndrome may develop without signs of PE and without high sFlt-1-levels. High LDH, liver and kidney dysfunction may be caused by pregnancy-indused MAHAT alone without PE and placenta ischemia.

nephrology, dialysis, transplantation/nephrology dialysis transplantation

MP266HELLP-SYNDROME A LINK TO AHUS: LABORATORY FEATURES OF PREECLAMPSIA (PE), HELLP-SYNDROME AND PREGNANCY-ASSOCIATED ATYPICAL HEMOLYTIC UREMIC SYNDROME (P-AHUS)