Open AccessIntracellular calcium increases in vascular smooth muscle cells with progression of chronic kidney disease in a rat model
Author(s) -
Stacey D. Rodenbeck,
Chad A. Zarse,
Mikaela L. McKenneyDrake,
Rebecca S. Bruning,
Michael Sturek,
Neal X. Chen,
Sharon M. Moe
Publication year - 2016
Publication title -
nephrology dialysis transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.654
H-Index - 168
eISSN - 1460-2385
pISSN - 0931-0509
DOI - 10.1093/ndt/gfw274
Subject(s) - medicine , endocrinology , vascular smooth muscle , kidney disease , calcium , parathyroid hormone , plasma membrane ca2+ atpase , serca , extracellular , calcium in biology , chemistry , biology , atpase , biochemistry , enzyme , smooth muscle
Vascular smooth muscle cells (VSMCs) exhibit phenotypic plasticity, promoting vascular calcification and increasing cardiovascular risk. Changes in VSMC intracellular calcium ([Ca 2+ ] i ) are a major determinant of plasticity, but little is known about changes in [Ca 2+ ] i in chronic kidney disease (CKD). We have previously demonstrated such plasticity in aortas from our rat model of CKD and therefore sought to examine changes in [Ca 2+ ] i during CKD progression.
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